What is coagulation? »Its Definition and Meaning [2019]

Coagulation is the process by which blood passes from its frequent liquid state to a semi-solid one , very similar to a gelatinous substance by which the so-called coagules are produced, this process is very important Since during the hemorrhages that occur in the different areas of the body it is vital that it occurs, in order to avoid excessive and irreparable loss of blood, allowing this bleeding to be repaired later, in the coagulation different elements intervene such as platelet activation and its adhesion, in addition to fibrin maturation.

There are certain lesions that can damage the structure of blood vessels, which causes them to initiate in the body a series of processes in order to prevent blood loss through said vessel , among these mechanisms are the complement of platelets, vasoconstriction of the vessel and subsequent or blood coagulation.The coagulation process is mainly due to a protein, specifically fibrinogen, which undergoes certain modifications that make it fibrin , which lacks the ability to solubilize, but it can bind to molecules similar to them forming macromolecules.It can then be said that a clot is a set of intertwined fibrins that, with the passage of time have captured other substances such as salts, water and some blood cells.

A large number of enzymatic processes enter the coagulation , which are related to each other, since act as a kind of reaction in chain, which as it progresses increases the range of action of it, since for example two molecules will give way to the activation of a larger number of molecules that in turn will activate another larger molecule cluster.In This process is 12 proteins that come into action, also certain phospholipids of the cell membrane and some Ca2 + ions, each of these elements receives the name of factor and is assigned with a number Roman, to differentiate them according to the place where they were discovered.

7 elements of coagulation are proenzymes which are synthesized in the liver, which once they have been Departures, they become proteases, belonging to the serine family, which have the ability to activate other enzymes in the chain or coagulation cascade.Certain factors of the chain require vitamin K so that in this way they can be synthesized in the liver, some of these factors are IX (beta antihemophilic) and VII (proconvertin).