What is obeticolic acid? »Its Definition and Meaning [2019]

The obeticolic acid is a synthetic acid used for the treatment of patients with primary biliary cirrhosis , or as it is now called “ primary biliary cholangitis ”.receptor modulates the metabolic pathway of bile acids, fibrosis and inflammation, reducing bile acid concentrations in hepatocytes.

Primary biliary cholangitis is a rare disease that affects mostly women between the ages of 40 and 60.The causes that cause it are ignored but it is considered autoimmune.

The application of this treatment in recent years has shown a breakthrough, for those who do not respond with traditional therapy .

The authorization to apply this drug was given very recently (2016) by The US Food and Drug Administration (FDA).

The administration of obetolic acid is through a dose of 10mg once a day, causing a decrease in colic concentrations and chenodeoxycholic acid .

For the treatment of primary biliary cholangitis , the recommended dose in adults is 5 mg once daily .After three months, if an adequate decrease in alkaline phosphatase and/or bilirubin has not yet been reached> Total and the person is accepting the drug well, the dose can be increased to 10 mg once a day, this being the maximum recommended dose.

Among the side effects that could cause this drug are: abdominal pain, pruritus, dizziness, sore throat, peripheral edema, palpitations, abnormalities in the thyroid , among others.

It can then be said that has been a breakthrough , the launch of this drug, which comes to benefit patients with liver conditions for which there were few treatment options.